Duskmantle Guildmage, and Mindcrank

Prerequisites

• Duskmantle Guildmage on the battlefield
• Mindcrank on the battlefield
• Each opponent has a life total that is less than or equal to their library size
• plus an additional for each opponent you have available

Steps

1. Activate Duskmantle Guildmage's first ability by paying , causing your opponent to lose life whenever a card is put into their graveyard this turn
2. Activate Duskmantle Guildmage's second ability by paying , causing an opponent to mill two cards
3. Duskmantle Guildmage triggers twice
4. Resolve the first trigger, causing the opponent to lose 1 life
5. Mindcrank triggers, causing the opponent to mill a card
6. Duskmantle Guildmage triggers, causing the opponent to lose 1 life
7. Repeat from step 5 until the opponent has a life total of zero, causing them to lose the game
8. Repeat from step 2 for each other opponent

Results

• Each opponent loses the game
• Infinite mill
• Near-infinite lifeloss