Ayara, First of Locthwain, Tree of Perdition, and Offspring's Revenge

Prerequisites

• Ayara, First of Locthwain on the battlefield
• Tree of Perdition in the graveyard
• Offspring's Revenge on the battlefield
• available

Steps

1. At the beginning of your combat phase, Offspring's Revenge triggers, exiling Tree of Perdition from your graveyard and creating a 1/1 copy of it with haste
2. When the Tree of Perdition token enters the battlefield, Ayara triggers
3. Holding priority, activate the Tree of Perdition token by tapping it, swapping an opponent's life total with Tree of Perdition's toughness
4. Resolve the Ayara trigger, causing you to gain 1 life and each opponent to lose 1 life
5. The opponent whose life total was swapped loses the game due to having zero or les life

Results

• Near-infinite lifeloss for target opponent
• Target opponent loses the game