Requiem Monolith, and Dawnsire, Sunstar Dreadnought

Prerequisites

• Requiem Monolith on the battlefield
• Dawnsire, Sunstar Dreadnought on the battlefield

Steps

1. Activate Requiem Monolith by tapping it, targeting a creature an opponent controls with toughness 2 or greater
2. Declare any creature as an attacker, triggering Dawnsire, dealing 100 damage to the creature targeted in step 1
3. The creature triggers, causing their controller to draw 100 cards and lose 100 life, thus losing the game due to drawing from an empty library

Results

• Target opponent loses the game
• Near-infinite lifeloss for target opponent