Mister Negative, Shadowcloak Vampire, and Darksteel Angel

Prerequisites

• Mister Negative in hand or in the command zone
• Shadowcloak Vampire on the battlefield
• Darksteel Angel on the battlefield

Steps

1. Activate Shadowcloak Vampire by paying life
2. Repeat step 1 until you have 0 life
3. Cast Mister Negative by paying plus commander tax if applicable
4. When Mister Negative enters, it triggers, swapping your life total with an opponent's
5. The opponent loses the game due to having 0 life

Results

• Near-infinite lifeloss for target opponent
• Target opponent loses the game