Chains of Mephistopheles, Dredger's Insight, Drogskol Reaver, and Golgari Thug

Prerequisites

• Chains of Mephistopheles on the battlefield
• Dredger's Insight on the battlefield
• Drogskol Reaver on the battlefield
• Golgari Thug in hand
• available

Steps

1. Attempt to draw a card
2. The draw will be replaced by Chains of Mephistopheles, instead causing you to discard Golgari Thug
3. Then, the draw will be replaced by Golgari Thug's dredge ability, causing you to mill cards and return Golgari Thug from your graveyard to your hand
4. Dredger's Insight's first ability triggers, causing you to gain 1 life
5. Drogskol Reaver triggers, attempting to draw a card
6. Repeat from step 2

Results

• Infinite self-mill
• Near-infinite lifegain
• Near-infinite lifegain triggers
• Near-infinite self-discard triggers