Pox Plague, and Astarion, the Decadent

Prerequisites

• Pox Plague in hand
• Astarion, the Decadent on the battlefield
• available

Steps

1. Cast Pox Plague by paying , causing each player to lose half their life, discard half their hand, and sacrifice half their permanents, rounded down
2. Ensure that you don't sacrifice Astarion
3. At the beginning of your end step, Astarion triggers, causing an opponent to lose life equal to the life they've lost this turn

Results

• Near-infinite lifeloss for all players