Heartless Hidetsugu, and Twinflame Tyrant

Prerequisites

• Heartless Hidetsugu on the battlefield
• Twinflame Tyrant on the battlefield
• At least one opponent has an even life total
• Heartless Hidetsugu does not have summoning sickness

Steps

1. Activate Heartless Hidetsugu by tapping it, dealing an amount of damage to each player equal to half their life total rounded down, except that the damage or life loss to opponents is doubled
2. Each opponent who had an even life total loses the game due to having zero life

Results

• Near-infinite damage
• Each opponent with an even life total loses the game