Yawgmoth, Thran Physician, Nest of Scarabs, and Relic Vial

Prerequisites

• Yawgmoth, Thran Physician on the battlefield
• Nest of Scarabs on the battlefield
• Relic Vial on the battlefield
• Your life total is at least 2
• You control at least one additional creature
• There is at least one other creature on the battlefield

Steps

1. Activate Yawgmoth by paying 1 life and sacrificing another creature
2. When the creature dies, Relic Vial triggers, causing you to gain 1 life and each opponent to lose 1 life
3. Resolve the Yawgmoth ability, putting a -1/-1 counter on any other creature and causing you to draw a card
4. If the creature who had the counter placed has 0 toughness, it dies as a state-based action
5. Nest of Scarabs triggers, creating a 1/1 Insect creature token
6. Repeat until your opponents do not control any more creatures, or until you draw your library
7. If you have cards remaining in your library, you may repeat this combo any time a creature enters the battlefield under an opponent's control

Results

• Near-infinite -1/-1 counters
• Near-infinite card draw
• Near-infinite death triggers
• Near-infinite draw triggers
• Near-infinite ETB
• Near-infinite lifegain triggers
• Near-infinite LTB
• Near-infinite sacrifice triggers
• Near-infinite lifeloss