Pox Plague, and Archfiend of Despair

Prerequisites

• Pox Plague in hand
• Archfiend of Despair on the battlefield
• available

Steps

1. Cast Pox Plague by paying , causing each player to lose half their life, discard half their hand, and sacrifice half their permanents, rounded down
2. Ensure that you don't sacrifice Archfiend of Despair
3. At the beginning of your end step, Archfiend of Despair triggers, causing each opponent to lose life equal to the life they've lost this turn

Results

• Near-infinite lifeloss for all players