Niv-Mizzet, the Firemind, Thornbite Staff, and Quietus Spike

Prerequisites

• Niv-Mizzet, the Firemind on the battlefield
• Thornbite Staff on the battlefield
• Quietus Spike on the battlefield
• Thornbite Staff and Quietus Spike attached to Niv-Mizzet
• Niv-Mizzet does not have summoning sickness

Steps

1. Activate Niv-Mizzet by tapping it, causing you to draw a card
2. Niv-Mizzet triggers, dealing 1 damage to a creature an opponent controls, and destroying the creature due to Niv-Mizzet's deathtouch
3. The creature dies, triggering Thornbite Staff, untapping Niv-Mizzet
4. Repeat
5. You may repeat this loop whenever a creature enters the battlefield under an opponent's control

Results

• Destroy all creatures that enter the battlefield under an opponent's control
• Destroy all nontoken creatures opponents control
• Near-infinite card draw
• Near-infinite draw triggers