Staff of Domination, Nyxbloom Ancient, Vizier of Tumbling Sands, and Izzet Boilerworks

Prerequisites

• Staff of Domination on the battlefield
• Nyxbloom Ancient on the battlefield
• Vizier of Tumbling Sands on the battlefield
• Izzet Boilerworks on the battlefield

Steps

1. Activate Izzet Boilerworks by tapping it, adding due to Nyxbloom Ancient Activate Vizier of Tumbling Sands by tapping it, untapping Izzet Boilerworks Activate Staff of Domination's third ability by paying and tapping it, untapping Vizier of Tumbling Sands
2. Activate Staff of Domination's first ability by paying , untapping it
3. Repeat

Results

• Infinite blue mana
• Infinite card draw
• Infinite draw triggers
• Infinite lifegain
• Infinite lifegain triggers
• Infinite red mana
• Infinite mana permanents you control can produce
• Infinite untap of permanents you control