Staff of Domination, Nyxbloom Ancient, Ioreth of the Healing House, and Dimir Aqueduct

Prerequisites

• Staff of Domination on the battlefield
• Nyxbloom Ancient on the battlefield
• Ioreth of the Healing House on the battlefield
• Dimir Aqueduct on the battlefield

Steps

1. Activate Dimir Aqueduct by tapping it, adding due to Nyxbloom Ancient Activate Ioreth of the Healing House by tapping it, untapping Dimir Aqueduct Activate Staff of Domination's third ability by paying and tapping it, untapping Ioreth of the Healing House
2. Activate Staff of Domination's first ability by paying , untapping it
3. Repeat

Results

• Infinite black mana
• Infinite blue mana
• Infinite card draw
• Infinite draw triggers
• Infinite lifegain
• Infinite lifegain triggers
• Infinite mana permanents you control can produce
• Infinite untap of permanents you control