- Grievous Wound
- Archfiend of Despair
- Target opponent loses the game
- Infinite lifeloss for target opponent
- Torgaar, Famine Incarnate
- Archfiend of Despair
- Infinite lifeloss for target opponent
- Target opponent loses the game
- Dire Fleet Ravager
- Archfiend of Despair
- Spark Double
- Each opponent loses the game
- Near-infinite lifeloss
- Sakashima of a Thousand Faces
- Dire Fleet Ravager
- Archfiend of Despair
- Each opponent loses the game
- Near-infinite lifeloss
- Dire Fleet Ravager
- Archfiend of Despair
- Clone
- Each opponent loses the game
- Near-infinite lifeloss
- Dire Fleet Ravager
- Archfiend of Despair
- Mirror Image
- Each opponent loses the game
- Near-infinite lifeloss
- Dire Fleet Ravager
- Archfiend of Despair
- Phantasmal Image
- Each opponent loses the game
- Near-infinite lifeloss
- Dire Fleet Ravager
- Archfiend of Despair
- Glasspool Mimic // Glasspool Shore
- Each opponent loses the game
- Near-infinite lifeloss
- Heartless Hidetsugu
- Archfiend of Despair
- Each opponent loses the game
- Near-infinite damage to all players
- Near-infinite lifeloss
- Magister Sphinx
- Archfiend of Despair
- Near-infinite lifeloss for target opponent
- Target opponent loses the game
- Blessed Wind
- Archfiend of Despair
- Near-infinite lifeloss for target opponent
- Target opponent loses the game
- Fraying Omnipotence
- Archfiend of Despair
- Near-infinite lifeloss
- Dire Fleet Ravager
- Lithoform Engine
- Archfiend of Despair
- Each opponent loses the game
- Near-infinite lifeloss
- Yarok, the Desecrated
- Dire Fleet Ravager
- Archfiend of Despair
- Each opponent loses the game
- Near-infinite lifeloss
- Harmonic Prodigy
- Dire Fleet Ravager
- Archfiend of Despair
- Each opponent loses the game
- Near-infinite lifeloss
- Shard of the Nightbringer
- Archfiend of Despair
- Infinite lifeloss for target opponent
- Target opponent loses the game
- Progenitus
- Dream Halls
- Archfiend of Despair
- Jarad, Golgari Lich Lord
- Infinite lifeloss
- Raving Dead
- Archfiend of Despair
- Near-infinite lifeloss for target opponent
- Target opponent loses the game
- Virtus the Veiled
- Archfiend of Despair
- Near-infinite lifeloss for target opponent
- Target opponent loses the game
- Quietus Spike
- Archfiend of Despair
- Near-infinite lifeloss for target opponent
- Target opponent loses the game
- Scytheclaw
- Archfiend of Despair
- Near-infinite lifeloss for target opponent
- Target opponent loses the game
- Zevlor, Elturel Exile
- Blood Tribute
- Archfiend of Despair
- Each opponent loses the game
- Near-infinite lifegain
- Near-infinite lifeloss
- Zevlor, Elturel Exile
- Peer into the Abyss
- Archfiend of Despair
- Each opponent loses the game
- Near-infinite card draw for all opponents
- Near-infinite draw triggers for all opponents
- Near-infinite lifeloss
- Xathrid Demon
- Malignus
- Archfiend of Despair
- Each opponent loses the game
- Syr Konrad, the Grim
- Morality Shift
- Archfiend of Despair
- Each opponents loses at least 40 life
- Havoc Festival
- Archfiend of Despair
- Each opponent loses the game
- Near-infinite lifeloss
- Scourge of the Skyclaves
- Archfiend of Despair
- Infinite lifeloss
- Illusions of Grandeur
- Fractured Identity
- Archfiend of Despair
- Calming Verse
- Near-infinite lifeloss
- Illusions of Grandeur
- Fractured Identity
- Archfiend of Despair
- Aether Snap
- Near-infinite lifeloss
- Archfiend of Despair
- Strionic Resonator
- Dire Fleet Ravager
- Each opponent loses the game
- Near-infinite lifeloss
Sets containing Archfiend of Despair
Archfiend of Despair appears in 2 different sets: